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1. WO2001058463 - NEURONAL CELL DIVISION

Publication Number WO/2001/058463
Publication Date 16.08.2001
International Application No. PCT/NL2001/000048
International Filing Date 25.01.2001
Chapter 2 Demand Filed 15.08.2001
IPC
A61K 35/30 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C12N 5/0793 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
079Neural cells
0793Neurons
CPC
A61K 35/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
C12N 2502/08
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2502Coculture with; Conditioned medium produced by
08cells of the nervous system
C12N 5/0619
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0618Cells of the nervous system
0619Neurons
Applicants
  • NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO [NL]/[NL] (AllExceptUS)
  • VAN NOORT, Johannes, Maria [NL]/[NL] (UsOnly)
  • BAJRAMOVIC, Jeffrey, John [NL]/[FR] (UsOnly)
  • BSIBSI, Malika [NL]/[NL] (UsOnly)
Inventors
  • VAN NOORT, Johannes, Maria
  • BAJRAMOVIC, Jeffrey, John
  • BSIBSI, Malika
Agents
  • PRINS, A., W.
Priority Data
00200412.508.02.2000EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NEURONAL CELL DIVISION
(FR) DIVISION DES CELLULES NEURONALES
Abstract
(EN) The present invention relates to a composition or factor which stimulates neurons, preferably human neurons, to cell division. The composition or factor can be recovered from white matter of brain, for instance in the form of an extract. The present composition or factor can be employed for the in vitro production of neurons, or as a component of pharmaceutical preparations for the treatment of brain disorders involving disturbed neuronal cell division.
(FR) La présente invention concerne une composition ou un facteur stimulant les neurones, de préférence les neurones humains, dans la division cellulaire. La composition ou le facteur peut être récupéré à partir de la substance blanche du cerveau, par exemple sous la forme d'un extrait. La présente composition ou le présent facteur peut être employé dans la production in vitro de neurones, ou en tant que constituant de préparations pharmaceutiques destinées au traitement de troubles du cerveau impliquant des troubles de la division des cellules neuronales.
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