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1. WO2001057210 - USE OF DENDROASPIN AS A VEHICLE FOR NON-DENDROASPIN DOMAINS

Publication Number WO/2001/057210
Publication Date 09.08.2001
International Application No. PCT/GB2001/000439
International Filing Date 05.02.2001
Chapter 2 Demand Filed 22.08.2001
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07K 14/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
Applicants
  • TRIGEN LIMITED [GB]/[GB]
Inventors
  • LU, Xinjie
  • KAKKAR, Vijay, Vir
Agents
  • HARRISON GODDARD FOOTE
Priority Data
0002625.205.02.2000GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF DENDROASPIN AS A VEHICLE FOR NON-DENDROASPIN DOMAINS
(FR) UTILISATION DE DENDROASPINE EN TANT QU'EXCIPIENT POUR DOMAINES EXEMPTS DE DENDROASPINE
Abstract
(EN)
The use of dendroaspin as a scaffold for one or more non-wild-type dendroaspin domains, the dendroaspin scaffold being modified in that the native RGD motif has been deleted or has been replaced by (i) an amino acid sequence having no integrin-binding activity or (ii) an integrin-binding amino acid sequence other than RGD which contains aspartic acid (D) or glutamic acid (E).
(FR)
L'invention concerne l'utilisation de dendroaspine en tant que structure pour au moins un domaine de dendroaspine qui n'est pas du type sauvage, la structure de dendroaspine étant modifiée du fait que le motif endogène RGD a été éliminé ou remplacé (i) par une séquence d'acides aminés ne possédant pas d'activité de liaison aux intégrines ou (ii) par une séquence d'acides aminés se liant aux intégrines qui diffère de RGD et renferme de l'acide aspartique (D) ou de l'acide glutamique (E).
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