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1. WO2001057090 - CANINE ALLERGY THERAPEUTIC RECOMBINANT CHIMERIC ANTI-IGE MONOCLONAL ANTIBODY

Publication Number WO/2001/057090
Publication Date 09.08.2001
International Application No. PCT/US2001/002924
International Filing Date 30.01.2001
Chapter 2 Demand Filed 31.08.2001
IPC
C07K 16/42 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42against immunoglobulins (anti-idiotypic antibodies)
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 16/4291
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
42against immunoglobulins
4283against an allotypic or isotypic determinant on Ig
4291against IgE
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • IDEXX LABORATORIES, INC. [US]/[US]
Inventors
  • LAWTON, Robert, L.
  • AIYAPPA, Ashok, P.
  • LIU, Wendy, W.
  • MERMER, Brion
  • GUO, Hongliang
  • KRAH, Eugene, R., III
Agents
  • HILLMAN, Lisa, M., W.
Priority Data
09/592,99812.06.2000US
60/179,62901.02.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CANINE ALLERGY THERAPEUTIC RECOMBINANT CHIMERIC ANTI-IGE MONOCLONAL ANTIBODY
(FR) ANTICORPS MONOCLONAL THERAPEUTIQUE ANTI-IGE CHIMERE DE RECOMBINAISON CONTRE L'ALLERGIE CANINE
Abstract
(EN) The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.
(FR) L'invention concerne des procédés et des compositions permettant de réduire les niveaux d'IgE chez les chiens. Ces procédés et ces compositions sont utiles pour le traitement de symptômes allergiques chez les chiens. L'invention concerne également des compositions d'anticorps monoclonal anti-IgE canin chimère, et des procédés d'utilisation de ces compositions pour le traitement d'une allergie. Dans des modes de réalisation préférentiels, les compositions susmentionnées peuvent agir en liant l'IgE soluble dans du plasma, ou en empêchant l'IgE de se lier aux récepteurs sur des mastocytes, des lymphocytes B, et des basophiles.
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