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1. WO2001057041 - 1-METHYLCARBAPENEM COMPOUNDS

Publication Number WO/2001/057041
Publication Date 09.08.2001
International Application No. PCT/JP2001/000664
International Filing Date 31.01.2001
Chapter 2 Demand Filed 31.01.2001
IPC
C07D 477/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
477Heterocyclic compounds containing 1-azabicyclo heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
10with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
12with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
16with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
20Sulfur atoms
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07D 477/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
477Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
10with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4 and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
12with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
16with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
20Sulfur atoms
Applicants
  • SANKYO COMPANY, LIMITED [JP]/[JP] (AllExceptUS)
  • KAWAMOTO, Isao [JP]/[JP] (UsOnly)
  • SHIMOJI, Yasuo [JP]/[JP] (UsOnly)
  • OHYA, Satoshi [JP]/[JP] (UsOnly)
Inventors
  • KAWAMOTO, Isao
  • SHIMOJI, Yasuo
  • OHYA, Satoshi
Agents
  • OHNO, Akio
Priority Data
2000-2101531.01.2000JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) 1-METHYLCARBAPENEM COMPOUNDS
(FR) COMPOSES 1-METHYLCARBAPEDEM
Abstract
(EN) 1-Methylcarbapenem compounds of the general formula (I) having excellent antimicrobial activities, pharmacologically acceptable prodrugs thereof, or pharmacologically acceptable salts of both, (I) wherein R1 is alkyl or the like; R2 and R3 are each independently hydrogen or the like; R4 is hydrogen or the like; R5 is a group having the formula: -C(=NH)R6 (wherein R6 is amino or the like); n is 0, 1 or 2; and A is alkylene or the like.
(FR) L'invention se rapporte à des composés 1-Méthylcarbapedem représentés par la formule (I), qui présentent d'excellentes propriétés antimicrobiennes, à des promédicaments pharmacologiquement acceptables de ces composés ou à des sels pharmacologiquement acceptables de ces composés et promédicaments. Dans la formule (I), R1 est alkyle ou analogue; R2 et R3 sont chacun indépendamment hydrogène ou analogue; R4 est hydrogène ou analogue; R5 est un groupe ayant la formule: -C(=NH)R6 (où R6 est amino ou analogue); n est égal à 0, 1 ou 2; et A est alcylène ou analogue.
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