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1. WO2001056606 - REMEDIES FOR OPHTHALMIC DISEASES

Publication Number WO/2001/056606
Publication Date 09.08.2001
International Application No. PCT/JP2001/000617
International Filing Date 30.01.2001
Chapter 2 Demand Filed 07.06.2001
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/1793
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
1793for cytokines; for lymphokines; for interferons
A61K 38/1841
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1841Transforming growth factor [TGF]
A61K 38/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
A61K 38/2006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
2006IL-1
A61K 38/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
38Albumins
Applicants
  • SANTEN PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • HARA, Hideaki [JP]/[JP] (UsOnly)
  • YONEDA, Shinji [JP]/[JP] (UsOnly)
  • MIYAWAKI, Nobuaki [JP]/[JP] (UsOnly)
  • TANIHARA, Hidenobu [JP]/[JP] (UsOnly)
Inventors
  • HARA, Hideaki
  • YONEDA, Shinji
  • MIYAWAKI, Nobuaki
  • TANIHARA, Hidenobu
Agents
  • KISHIMOTO, Einosuke
Priority Data
2000-2144631.01.2000JP
2000-26882905.09.2000JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) REMEDIES FOR OPHTHALMIC DISEASES
(FR) REMEDES POUR TROUBLES OPHTALMIQUES
Abstract
(EN)
Remedies for ophthalmic diseases such as glaucoma and retinal diseases. Compounds having an interleukin-1 inhibitory activity (for example, endogenous interleukin-1 receptor antagonist proteins, interleukin-1 neutralizing antibodies) have remarkable effects of inhibiting a decrease in the cell count in retinal ganglial cell layer, preventing entoretinal layer from thinning, and lowering ocular tension.
(FR)
L'invention se rapporte à des remèdes pour troubles ophtalmiques tels que le glaucome et les affections rétiniennes. Les composés présentant une activité d'inhibition de l'interleukine-1 (les protéines antagonistes des récepteurs de l'interleukine-1 endogènes, les anticorps neutralisant l'interleukine-1) présentent des effets remarquables s'agissant d'inhiber la réduction du nombre de cellules dans la couche des cellules ganglionnaires de la rétine, d'empêcher l'amincissement de la couche endorétinienne et d'abaisser la tension oculaire.
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