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1. WO2001056603 - CD40-BINDING APC-ACTIVATING MOLECULES

Publication Number WO/2001/056603
Publication Date 09.08.2001
International Application No. PCT/US2001/003378
International Filing Date 01.02.2001
Chapter 2 Demand Filed 23.08.2001
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/39541
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39541against normal tissues, cells
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 16/2818
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2818against CD28 or CD152
Applicants
  • TANOX, INC. [US]/[US]
Inventors
  • THOMAS, David
  • DE BOER, Mark
  • RES, Pieter, C., J., M.
  • SIMONS, Peter, J.
Agents
  • MIRABEL, Eric, P.
Priority Data
60/178,93401.02.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CD40-BINDING APC-ACTIVATING MOLECULES
(FR) MOLECULES D'ACTIVATION DES APC SE LIANT AU CD40
Abstract
(EN) Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells ('APCs'), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
(FR) La présente invention concerne des molécules anti-CD40 agonistes, incluant des anticorps monoclonaux, qui peuvent se lier à des cellules de présentation d'antigène (APC) humaines professionnelles et non professionnelles et les stimuler, renforcer l'effet stimulant du CD40L sur les cellules positives CD40 et/ou induire une maturation phénotypique des cellules dendritiques dérivées de monocytes. L'invention concerne plus particulièrement divers tels anticorps monoclonaux, ainsi que des lignées cellulaires les produisant, déposés auprès de la 'American Type Culture Collection'.
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