Processing

Please wait...

Settings

Settings

Goto Application

1. WO2001055385 - VECTOR CONSTRUCTS FOR GENE-THERAPY MEDIATED RADIONUCLIDE THERAPY OF UNDIFFERENTIATED AND MEDULLARY THYROID CARCINOMAS AND NON-THYROIDAL TUMOURS AND THE METASTASES THEREOF

Publication Number WO/2001/055385
Publication Date 02.08.2001
International Application No. PCT/DE2001/000372
International Filing Date 29.01.2001
Chapter 2 Demand Filed 08.08.2001
IPC
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
A61K 47/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 51/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
12characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
CPC
A61K 38/177
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
A61K 38/179
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
179for growth factors; for growth regulators
A61K 38/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
A61K 47/6901
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
A61K 47/6913
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
6913the liposome being modified on its surface by an antibody
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants
  • MEDIZINISCHE HOCHSCHULE HANNOVER [DE]/[DE] (AllExceptUS)
  • PETRICH, Thorsten [DE]/[DE] (UsOnly)
  • PÖTTER, Eyck [DE]/[DE] (UsOnly)
Inventors
  • PETRICH, Thorsten
  • PÖTTER, Eyck
Agents
  • DEHMEL, Albrecht
Priority Data
100 03 653.828.01.2000DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) VEKTORKONSTRUKTE ZUR GENTHERAPEUTISCH VERMITTELTEN RADIONUKLID-THERAPIE ENTDIFFERENZIERTER UND MEDULLÄRER SCHILDDRÜSEN-KARZINOME SOWIE NICHT-THYREOIDALER TUMORE UND IHRER METASTASEN
(EN) VECTOR CONSTRUCTS FOR GENE-THERAPY MEDIATED RADIONUCLIDE THERAPY OF UNDIFFERENTIATED AND MEDULLARY THYROID CARCINOMAS AND NON-THYROIDAL TUMOURS AND THE METASTASES THEREOF
(FR) STRUCTURES DE VECTEURS DESTINEES A LA THERAPIE PAR RADIONUCLEIDES EN THERAPIE GENETIQUE DE CARCINOMES DEDIFFERENCIES ET MEDULLAIRES AINSI QUE DE TUMEURS NON-THYROIDALES ET DE LEURS METASTASES
Abstract
(DE) Die vorliegende Erfindung betrifft Vektorkonstrukte, umfassend Vektor-DNA einschliesslich regulatorischer Sequenzen sowie das NIS-Gen, das für den Natrium/Iodidsymporter kodiert, und das TPO-Gen, das für die thyreoidale Peroxidase kodiert, sowie deren Verwendung zur Herstellung eines Medikaments/Diagnostikums zur Behandlung/Diagnose von Tumorerkrankungen, wobei die Behandlung vor einer oder gleichzeitig mit einer Radionuklid-Therapie, insbesondere mit 131-Iod oder 211-Astat, erfolgt. Die vorliegende Erfindung betrifft weiterhin die Verwendung von zwei oder von mehreren Vektorkonstrukten zur Herstellung eines Medikaments/Diagnostikums zur Behandlung/Diagnose von Tumorerkrankungen.
(EN) The invention relates to vector constructs, comprising vector DNA which includes regulatory sequences, the NIS gene coding for the sodium/iodide symporter, the TPO gene coding for thyroidal peroxidase and use thereof for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states, whereby treatment occurs before or concurrent with a radionuclide therapy, in particular, with iodine-131, or astatine-211. The invention further relates to use of two or several vector constructs for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states.
(FR) L'invention concerne des structures de vecteurs constituées d'ADN de vecteur comportant des séquences régulatrices, du gène NIS codant le symport sodium/iodure, et du gène TPO codant la peroxydase thyroïdale, ainsi que leur utilisation dans la fabrication d'un agent pharmaceutique/diagnostique destiné au traitement/diagnostic de maladies tumorales, le traitement étant effectuée au moyen d'une thérapie par radionucléides ou en association avec une thérapie par radionucléides, en particulier avec de l'iode 131, ou de l'astate 211. La présente invention concerne également l'utilisation d'au moins deux structures de vecteurs dans la fabrication d'un agent pharmaceutique/diagnostique destiné au traitement/diagnostic de maladies tumorales.
Latest bibliographic data on file with the International Bureau