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1. WO2001055219 - scsCNTFR/NNT-1 FUSION PROTEIN

Publication Number WO/2001/055219
Publication Date 02.08.2001
International Application No. PCT/FR2001/000254
International Filing Date 26.01.2001
Chapter 2 Demand Filed 20.08.2001
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
C07K 14/71 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
C07K 14/715 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • PIERRE FABRE MEDICAMENT [FR]/[FR] (AllExceptUS)
  • ELSON, Greg [GB]/[FR] (UsOnly)
  • GAUCHAT, Jean-François [CH]/[FR] (UsOnly)
Inventors
  • ELSON, Greg
  • GAUCHAT, Jean-François
Agents
  • MARTIN, Jean-Jacques
Priority Data
00/0103527.01.2000FR
00/1309012.10.2000FR
Publication Language French (fr)
Filing Language French (FR)
Designated States
Title
(EN) scsCNTFR/NNT-1 FUSION PROTEIN
(FR) PROTEINE DE FUSION scsCNTFR/NNT-1
Abstract
(EN) The invention concerns a scsCNTFR/NNT-1 fusion protein comprising a NNT-1 protein, a sCNTFR$g(a) protein and a binding element which binds said two proteins. The invention also concerns a composition comprising said fusion protein as medicine for preventing and/or treating neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson's disease or Huntington's disease, for maintaining muscle mass in paralyzed persons, for treating obesity or cancer.
(FR) La présente invention a pour objet une protéine de fusion scsCNTFR/NNT-1 comprenant une protéine NNT-1, une protéine sCNTFR$g(a) et un élément de liaison qui lie ces deux protéines. L'invention comprend également une composition comprenant ladite protéine de fusion comme médicament pour la prévention et/ou le traitement de maladies neurodégénératives telles que la sclérose latérale amyotrophique, la maladie de Parkinson ou la maladie de Huntington; pour la maintenance de la masse musculaire chez les paralysés; pour le traitement de l'obésité ou du cancer.
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