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1. WO2001055125 - A PROCESS FOR THE PREPARATION OF QUETIAPINE AND INTERMEDIATES THEREFOR

Publication Number WO/2001/055125
Publication Date 02.08.2001
International Application No. PCT/HU2001/000010
International Filing Date 24.01.2001
Chapter 2 Demand Filed 09.08.2001
IPC
C07D 281/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02Seven-membered rings
04having the hetero atoms in positions 1 and 4
08condensed with carbocyclic rings or ring systems
12condensed with two six-membered rings
16-condensed
C07D 295/215 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
20by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
215Radicals derived from nitrogen analogues of carbonic acid
CPC
C07D 281/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02Seven-membered rings
04having the hetero atoms in positions 1 and 4
08condensed with carbocyclic rings or ring systems
12condensed with two six-membered rings
16[b, f]-condensed
C07D 295/215
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
20by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
215Radicals derived from nitrogen analogues of carbonic acid
Applicants
  • EGIS GYÓGYSZERGYÁR RT. [HU]/[HU] (AllExceptUS)
  • BÓZSING, Dániel [HU]/[HU] (UsOnly)
  • KOVÁNYINÉ LAX, Györgyi [HU]/[HU] (UsOnly)
  • SIMIG, Gyula [HU]/[HU] (UsOnly)
  • RÁKÓCZY, Györgyné [HU]/[HU] (UsOnly)
  • TÖMPE, Péter [HU]/[HU] (UsOnly)
  • KRASZNAI, György [HU]/[HU] (UsOnly)
  • VERECZKEYNÉ DONÁTH, Györgyi [HU]/[HU] (UsOnly)
  • NAGY, Kálmán [HU]/[HU] (UsOnly)
Inventors
  • BÓZSING, Dániel
  • KOVÁNYINÉ LAX, Györgyi
  • SIMIG, Gyula
  • RÁKÓCZY, Györgyné
  • TÖMPE, Péter
  • KRASZNAI, György
  • VERECZKEYNÉ DONÁTH, Györgyi
  • NAGY, Kálmán
Agents
  • ADVOPATENT OFFICE OF PATENT AND TRADEMARK ATTORNEYS
Priority Data
P 000028325.01.2000HU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A PROCESS FOR THE PREPARATION OF QUETIAPINE AND INTERMEDIATES THEREFOR
(FR) PROCÉDÉ DE PRÉPARATION DE QUÉTIAPINE ET DES SES INTERMÉDIAIRES
Abstract
(EN)
The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a halo atom, is reacted with ethylene glycol.
(FR)
Cette invention a trait à un nouveau procédé de préparation de 11-[4-/2-(2-hydroxyéthoxy)éthyl/-1-pipérazinyl]dibenzo[b,f]-1,4-thiazépine, correspondant à la formule (I), substance connue sous le nom de quétiapine. On fait réagir, dans le cadre de cette invention, un dérivé d'haloéthylpipérazinylthiazépine, correspondant à la formule (VIII), avec de l'éthylèneglycol.
Also published as
HRP20020579A
PLP.355726
ROa 2002 01010
Latest bibliographic data on file with the International Bureau