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1. WO2001044180 - A FACTORY SCALE PROCESS FOR PRODUCING CRYSTALLINE ATORVASTATIN TRIHYDRATE HEMI CALCIUM SALT

Publication Number WO/2001/044180
Publication Date 21.06.2001
International Application No. PCT/IE2000/000150
International Filing Date 18.12.2000
Chapter 2 Demand Filed 13.06.2001
IPC
C07D 207/34 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
CPC
C07D 207/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 405/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • WARNER LAMBERT RESEARCH AND DEVELOPMENT IRELAND LIMITED [IE]/[IE] (AllExceptUS)
  • TULLY, William [IE]/[IE] (UsOnly)
Inventors
  • TULLY, William
Agents
  • O'BRIEN, John, A.
Priority Data
PCT/IE99/0013217.12.1999IE
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) A FACTORY SCALE PROCESS FOR PRODUCING CRYSTALLINE ATORVASTATIN TRIHYDRATE HEMI CALCIUM SALT
(FR) PROCEDE DE PRODUCTION A L'ECHELLE INDUSTRIELLE DE SEL D'HEMI-CALCIUM TRIHYDRATE D'ATORVASTATINE CRISTALLISE
Abstract
(EN) A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt includes the addition of extra methyl tert-butyl ether to the reaction mixture to supersaturate the crystallisation matrix. A seed slurry is made up in a make-up/delivery vessel and delivered, under pressure, to the reaction mixture. The process produces crystalline atorvastatin calcium, having structure (I) within a consistent size range on a factory scale.
(FR) La présente invention concerne un procédé de production à l'échelle industrielle de sel d'hémi-calcium trihydraté d'atorvastatine cristallisé, comprenant l'adjonction de méthyl tert-butyl éther supplémentaire au mélange réactionnel pour sursaturer la matrice de cristallisation. Une suspension de germe est préparée dans un récipient de préparation et de distribution, puis ajoutée, sous pression, au mélange réactionnel. Le procédé permet d'obtenir du calcium d'atorvastatine cristallisé, de structure (I), à grande échelle industrielle.
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ININ/PCT/2002/634/KOLThis application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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