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1. WO2001043721 - DOSAGE FORMS HAVING A BARRIER LAYER TO LASER ABLATION

Publication Number WO/2001/043721
Publication Date 21.06.2001
International Application No. PCT/US2000/033494
International Filing Date 11.12.2000
Chapter 2 Demand Filed 09.07.2001
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
CPC
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Applicants
  • ALZA CORPORATION [US]/[US]
Inventors
  • GEERKE, Johan, H.
Agents
  • SIMBOLI, Paul, B.
Priority Data
60/172,37116.12.1999US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DOSAGE FORMS HAVING A BARRIER LAYER TO LASER ABLATION
(FR) FORMES POSOLOGIQUES POURVUES D'UNE COUCHE BARRIERE A L'ABLATION PAR LASER
Abstract
(EN) A dosage form for delivery of a therapeutic agent to a subject is described. The dosage form contains: (a) an outer wall defining an interior compartment; (b) within the interior compartment, a therapeutic agent; (c) at least one exit orifice formed by laser ablation of the outer wall for release of the agent therethrough, and (d) a barrier layer disposed between the outer wall and the interior compartment in at least a region corresponding to the exit orifice. The barrier layer comprises a material that allows the barrier layer to remain intact during laser-formation of the at least one exit orifice in the outer wall. Also disclosed is a method for controlling the depth of laser ablation of a dosage form during laser formation of an exit orifice in an outer wall of the dosage form.
(FR) L'invention concerne une forme posologique destinée à l'administration d'un agent thérapeutique à un patient. Cette forme posologique contient (a) une paroi extérieure définissant une compartiment interne ; (b) un agent thérapeutique situé dans ledit compartiment interne ; (c) au moins un orifice de sortie formé par ablation par laser sur la paroi extérieure, destiné à la libération de l'agent, et (d) une couche barrière située entre la paroi extérieure et le compartiment interne, au moins dans une région correspondant à l'orifice de sortie. Cette couche barrière est constituée d'une matière lui permettant de demeurer intacte lors de la formation par laser d'au moins un orifice de sortie dans la paroi extérieure. L'invention concerne également un procédé de commande de la profondeur de l'ablation par laser d'une forme posologique au cours de la formation, par laser, d'un orifice de sortie dans sa paroi extérieure.
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