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1. (WO2001038584) NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/038584    International Application No.:    PCT/US2000/032265
Publication Date: 31.05.2001 International Filing Date: 21.11.2000
Chapter 2 Demand Filed:    08.06.2001    
IPC:
C07D 487/04 (2006.01), C07H 21/00 (2006.01), C07K 5/06 (2006.01), C07K 5/078 (2006.01), C07K 14/00 (2006.01), C12Q 1/68 (2006.01)
Applicants: EPOCH BIOSCIENCES, INC. [US/US]; 21720-23rd Drive, S.E. #150, Bothell, WA 98021 (US)
Inventors: GALL, Alexander, A; (US).
KUTYAVIN, Igor, V.; (US).
VERMEULEN, Nicolaas, M., J.; (US).
DEMPCY, Robert, O.; (US)
Agent: KEZER, William, B.; Townsend and Townsend and Crew LLP, 8th Floor, Two Embarcadero Center, San Francisco, CA 94111-3834 (US)
Priority Data:
09/447,936 23.11.1999 US
Title (EN) NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF
(FR) OLIGOMERES DEPOURVUS D'AGREGATION ET D'EXTINCTION DE FLUORESCENCE COMPRENANT DES ANALOGUES DE NUCLEOTIDES; METHODES DE SYNTHESE ET UTILISATION CORRESPONDANTE
Abstract: front page image
(EN)The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.
(FR)L'invention concerne des compositions et des méthodes permettant d'effectuer une analyse par hybridation au moyen d'oligomères d'ADN, d'ARN, de protéines PNA et chimériques dans laquelle une ou plusieurs bases purine sont substituées par une pyrazolo[5,4-d]pyrimidine ou par un analogue de 7-déazapurine purine. Il est possible de réduire l'auto-agrégation et l'extinction de fluorescence lorsque les oligomères sont utilisés dans différentes méthodes liées à l'hybridation. L'invention concerne également des méthodes de synthèse, ainsi que de nouveaux précurseurs synthétiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)