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1. (WO2001038561) METHODS OF USE OF PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBACTERIAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/038561 International Application No.: PCT/US2000/032346
Publication Date: 31.05.2001 International Filing Date: 27.11.2000
Chapter 2 Demand Filed: 14.06.2001
IPC:
A61K 31/165 (2006.01) ,A61K 31/381 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/4453 (2006.01) ,A61K 31/55 (2006.01) ,A61K 31/63 (2006.01) ,C07C 259/06 (2006.01) ,C07D 295/185 (2006.01) ,C07D 333/68 (2006.01) ,C12Q 1/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
381
having five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4453
only substituted in position 1, e.g. propipocaine, diperodon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
63
Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
259
Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04
without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
06
having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16
acylated on ring nitrogen atoms
18
by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
182
Radicals derived from carboxylic acids
185
from aliphatic carboxylic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50
condensed with carbocyclic rings or ring systems
52
Benzo [b] thiophenes; Hydrogenated benzo [b] thiophenes
62
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
68
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
Applicants:
QUESTCOR PHARMACEUTICALS, INC. [US/US]; 26118 Research Road Hayward, CA 94545, US
Inventors:
FRECHETTE, Roger; US
DAVIS, Susan; GB
JAEGER, Chris; US
CHONG, Lee; US
KNAP, Ania; US
WITHERELL, Gary; US
MOEHLE, Charles; US
GLUCHOWSKI, Charles; US
Agent:
POISSANT, Brian, M. ; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
09/449,41929.11.1999US
Title (EN) METHODS OF USE OF PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBACTERIAL AGENTS
(FR) METHODES D'UTILISATION D'INHIBITEURS DE LA PEPTIDE DEFORMYLASE EN TANT QUE NOUVEAUX AGENTS ANTIBACTERIENS
Abstract:
(EN) The present invention relates to novel drug discovery assays which specifically target peptide deformylase containing the typically unstable native catalytic iron metal center. The present invention further relates to methods of identifying compounds which have greater than 10-fold, and preferably greater than 100-fold selectivity for peptide deformylase over other metalloproteases. The invention further provides for compounds having antibacterial activity identified by the assays of the invention, methods of using the compounds to treat bacterial infections and pharmaceutical compositions containing the compounds of the invention.
(FR) L'invention concerne de nouveaux dosages de recherche médicamenteuse qui ciblent spécifiquement la peptide déformylase contenant le centre de fer catalytique généralement instable. L'invention concerne également des méthodes permettant d'identifier des composés qui présentent un sélectivité plus de 10 fois, et de préférence plus de 100 fois supérieure pour la peptide déformylase que pour d'autres métalloprotéases. L'invention concerne également des composés présentant une activité antibactérienne identifiés au moyen des dosages selon l'invention, des méthodes d'utilisation de ces composés pour traiter des infections bactériennes ainsi que des compositions pharmaceutiques contenant les composés selon l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)