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1. (WO2001038528) CELL PROLIFERATION INHIBITORY PROTEIN, POLYNUCLEOTIDE, ANTISENSE POLYNUCLEOTIDE TO THE POLYNUCLEOTIDE, AND CELL PROLIFERATION INHIBITORS, CANCER DIAGNOSTICS, CANCER REMEDIES AND COMPOSITIONS FOR GENE THERAPY BY USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/038528    International Application No.:    PCT/JP2000/005879
Publication Date: 31.05.2001 International Filing Date: 30.08.2000
Chapter 2 Demand Filed:    28.12.2000    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/47 (2006.01)
Applicants: HISAMITSU PHARMACEUTICAL CO., INC. [JP/JP]; 408, Tashirodaikan-machi, Tosu-shi, Saga 841-0017 (JP) (For All Designated States Except US).
NAMBA, Masayoshi [JP/JP]; (JP) (For US Only).
TSUJI, Toshiya [JP/JP]; (JP) (For US Only)
Inventors: NAMBA, Masayoshi; (JP).
TSUJI, Toshiya; (JP)
Agent: HASEGAWA, Yoshiki; Soei Patent and Law Firm, Okura-honkan, 6-12, Ginza 2-chome, Chuo-ku, Tokyo 104-0061 (JP)
Priority Data:
11/330604 19.11.1999 JP
Title (EN) CELL PROLIFERATION INHIBITORY PROTEIN, POLYNUCLEOTIDE, ANTISENSE POLYNUCLEOTIDE TO THE POLYNUCLEOTIDE, AND CELL PROLIFERATION INHIBITORS, CANCER DIAGNOSTICS, CANCER REMEDIES AND COMPOSITIONS FOR GENE THERAPY BY USING THE SAME
(FR) PROTEINE INHIBITRICE DE LA PROLIFERATION CELLULAIRE, POLYNUCLEOTIDE, POLYNUCLEOTIDE ANTISENS DE CE POLYNUCLEOTIDE, INHIBITEURS DE PROLIFERATION CELLULAIRE, DIAGNOSTICS DE CANCERS, REMEDES ANTICANCEREUX ET COMPOSITION POUR THERAPIE GENIQUE LES UTILISANT
Abstract: front page image
(EN)A gene showing reduction or disappearance of expression in immortalized cells involving cancer cells is isolated and the DNA sequence thereof is determined. Further, a cell proliferation inhibitory protein is produced by expressing this gene and the gene and the protein are used as diagnostics or remedies to be used in gene diagnosis, gene therapy, etc. for diseases such as cancer.
(FR)Dans le cadre de cette invention, on isole un gène faisant montre d'une diminution ou d'une disparition d'expression dans des cellules immortalisées, notamment des cellules cancéreuses, et l'on détermine la séquence d'ADN de ce gène. On produit également une protéine inhibitrice de la prolifération cellulaire par expression dudit gène. On utilise ce gène et cette protéine comme agents diagnostiques ou remèdes, utilisables en matière de diagnostic génique, de thérapie génique, etc., s'agissant de maladies telles que le cancer.
Designated States: AU, CA, CN, JP, KR, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)