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Machine translation
1. (WO2001038527) NOVEL PROTEIN TAB2
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/038527    International Application No.:    PCT/JP1999/006466
Publication Date: 31.05.2001 International Filing Date: 19.11.1999
Chapter 2 Demand Filed:    22.12.1999    
IPC:
A61K 38/00 (2006.01), C07K 14/47 (2006.01), C12Q 1/48 (2006.01), G01N 33/68 (2006.01)
Applicants: MATSUMOTO, Kunihiro [JP/JP]; (JP)
Inventors: MATSUMOTO, Kunihiro; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Building 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 300-0847 (JP)
Priority Data:
Title (EN) NOVEL PROTEIN TAB2
(FR) NOUVELLE PROTEINE TAB2
Abstract: front page image
(EN)A novel signal transducer TAB2 which acts as an adapter molecule of TRAF6 and TAK1 and mediates the activation of TAK1 in the signal transduction of IL-1 is isolated. TAB2 induces the activation of NF-$g(k)B and JNK by IL-1. The signal transduction by IL-1 is inhibited by inhibiting the signal transduction of TAB2 with the use of a dominant negative variant of TAB2. A compound inhibiting the signal transduction in TAB2 is useful as an anti-inflammatory drug.
(FR)Selon cette invention, on a isolé un nouveau transducteur de signal TAB2 qui agit comme une molécule adaptatrice de TRAF6 et TAK1 et modifie légèrement l'activation de TAK1 dans la transduction de signal d'IL-1. TAB2 induit l'activation de NF-$g(k)B et JNK par IL-1. La transduction de signal par IL-1 est inhibée par inhibition de la transduction de signal de TAB2 au moyen d'une variante négative dominante de TAB2. Un composé inhibant la transduction de signal dans TAB2 est utile comme médicament anti-inflammatoire.
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)