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Machine translation
1. (WO2001038526) HUMAN TNF RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/038526    International Application No.:    PCT/GB2000/004438
Publication Date: 31.05.2001 International Filing Date: 21.11.2000
Chapter 2 Demand Filed:    11.06.2001    
IPC:
A61K 38/00 (2006.01), C07K 14/715 (2006.01), G01N 33/68 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN (GB) (For All Designated States Except US).
KITSON, Jeremy, David, Alistair [GB/GB]; (GB) (For US Only)
Inventors: KITSON, Jeremy, David, Alistair; (GB)
Agent: REES, Marion, L.; GlaxoSmithKline, Two New Horizons Court, Brentford, Middlesex TW8 9EP (GB)
Priority Data:
9927681.8 23.11.1999 GB
Title (EN) HUMAN TNF RECEPTOR
(FR) RÉCEPTEUR DE TNF HUMAIN
Abstract: front page image
(EN)An isolated TNF-receptor polypeptide comprises the amino acid sequence of SEQ ID NO: 2, a variant thereof which is capable of activating NFkB, or a fragment of either thereof whcih is capable of activating NFkB. Polynucleotides encoding such a TNF receptor are also described. A method for identification of a substance that modulates TNF receptor acitivity comprises contacting a polypeptide of the invention with a test substance in the presence of a reporter whose activity is mediated by NFkB and monitoring NFkB mediated activity.
(FR)L'invention concerne un polypeptide isolé de récepteur de TNF, qui comporte la séquence d'acides aminés SEQ ID NO: 2, une variante de celle-ci capable d'activer NFkB, ou un fragment du polypeptide ou de la variante capable d'activer NFkB. L'invention concerne également des polynucléotides codant pour ce récepteur de TNF. Un procédé d'identification d'une substance qui module l'activité du récepteur de TNF comporte les étapes consistant à mettre en contact un polypeptide de l'invention avec une substance d'essai en présence d'un rapporteur dont l'activité dépend de NFkB, et à surveiller l'activité dépendant de NFkB.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)