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1. (WO2001038519) NOVEL NUCLEIC ACID AND POLYPEPTIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/038519 International Application No.: PCT/AU2000/001435
Publication Date: 31.05.2001 International Filing Date: 24.11.2000
Chapter 2 Demand Filed: 26.02.2001
IPC:
A61K 38/00 (2006.01) ,A61Q 5/10 (2006.01) ,C07K 14/705 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
5
Preparations for care of the hair
10
Preparations for permanently dyeing the hair
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: LITTLE, Melissa[AU/AU]; AU (UsOnly)
YAMADA, Toshiya[JP/AU]; AU (UsOnly)
HOLMES, Gregory[AU/US]; US (UsOnly)
GEORGAS, Kylie[AU/AU]; AU (UsOnly)
KOLLE, Gabriel[AU/AU]; AU (UsOnly)
WILKINSON, Lorine[AU/AU]; AU (UsOnly)
THE UNIVERSITY OF QUEENSLAND[AU/AU]; St Lucia Brisbane, QLD 4072, AU (AllExceptUS)
Inventors: LITTLE, Melissa; AU
YAMADA, Toshiya; AU
HOLMES, Gregory; US
GEORGAS, Kylie; AU
KOLLE, Gabriel; AU
WILKINSON, Lorine; AU
Agent: FISHER ADAMS KELLY; Level 13 AMP Place 10 Eagle Street Brisbane, QLD 4000, AU
Priority Data:
PQ 434826.11.1999AU
Title (EN) NOVEL NUCLEIC ACID AND POLYPEPTIDE
(FR) NOUVEL ACIDE NUCLEIQUE ET NOUVEAU POLYPEPTIDE
Abstract:
(EN) A novel isolated nucleic acid which corresponds to a gene located on human chromosome 2p21-16.3 is provided, and a polypeptide encoded thereby, together with mouse and chicken orthologs. The encoded polypeptides share a PGECCPLP motif and include an insulin-like growth factor binding domain, cysteine-rich repeats, an RGD motif and transmembrane domain, and interact with members of the transforming growth factor superfamily. The nucleic acids of the invention, and polypeptides encoded thereby, may be useful in the diagnosis and treatment of diseases including eye defects, neurodegenerative diseases, renal and kidney disease, bone and tooth abnormalities, wounds and skin damage.
(FR) La présente invention concerne un nouvel acide nucléique isolé qui correspond à un gène situé sur le chromosome 2p21-16.3 humain, et un polypeptide codé par celui-ci, de même que des orthologues de souris et de poulet. Ces polypeptides codés partagent un motif structurel PGECCPLP et comprennent un domaine de liaison de facteur de croissance semblable à l'insuline, des séquences d'ADN répétées riches en cystéine, un motif structurel RGD et un domaine transmembranaire, et ils interagissent avec des membres de la superfamille du facteur de croissance transformant. Les acides nucléiques de l'invention et les polypeptides codés par ceux-ci, peuvent convenir pour le diagnostic et le traitement de maladies comprenant des défauts oculaires, des maladies neurodégénératives, des maladies rénales, des anomalies osseuses et dentaires, des blessures et des dégradations cutanées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)