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1. (WO2001038428) MICROPOROUS POLYMER MATRICES

Pub. No.:    WO/2001/038428    International Application No.:    PCT/GB2000/004472
Publication Date: Fri Jun 01 01:59:59 CEST 2001 International Filing Date: Sat Nov 25 00:59:59 CET 2000
IPC: A61L 27/18
A61L 27/56
C08G 63/08
C08J 9/28
Applicants: THE UNIVERSITY OF NOTTINGHAM
COOMBES, Allan, Gerald, Arthur
DOWNES, Sandra
WALLACE, William, Angus
Inventors: COOMBES, Allan, Gerald, Arthur
DOWNES, Sandra
WALLACE, William, Angus
Title: MICROPOROUS POLYMER MATRICES
Abstract:
A method for the manufacture of a microporous polymer matrix comprises the steps of: a) introducing into a mould a solution of polymer in a solvent, and b) adding a precipitant to the solution so as to cause precipitation of the polymer from the solution in a form which retains the shape of the mould upon removal from the mould. Useful polymers for carrying out the method of the invention are those which show a tendency to crystallise from solution on solvent extraction. These include poly(L.lactide) or copolymers of poly(L.lactide) and a poly (α-hydroxy acid) which will dissolve in acetone and subsequently crystallise upon solvent extraction. The preferred polymer is poly(ε-caprolactone). The precipitant is preferably a solvent in which the polymer is substantially insoluble. Preferred precipitants are polar solvents such as alcohols, in particular methanol.