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1. (WO2001038392) NOVEL TRANSCRIPTION FACTOR AND DNA THEREOF

Pub. No.:    WO/2001/038392    International Application No.:    PCT/JP2000/008257
Publication Date: Fri Jun 01 01:59:59 CEST 2001 International Filing Date: Sat Nov 25 00:59:59 CET 2000
IPC: A61K 38/00
C07K 14/47
C07K 14/51
Applicants: TAKEDA CHEMICAL INDUSTRIES, LTD.

YOSHIMURA, Koji

HIKICHI, Yuichi

NOGUCHI, Kenichi

Inventors: YOSHIMURA, Koji

HIKICHI, Yuichi

NOGUCHI, Kenichi

Title: NOVEL TRANSCRIPTION FACTOR AND DNA THEREOF
Abstract:
A polypeptide having an activity of binding specifically to the cis-element of ChM-I gene promoter and promoting the transcription of the ChM-I gene. Therefore, the polypeptide and its DNA are useful as preventives/remedies for diseases such as rheumatoid arthritis, arthrosis deformans, osteoporosis, bone fracture and cancer. Also, the above-described polypeptide and DNA or a transformant thereof are usable in screening, for example, a compound promoting or inhibiting the activity of the polypeptide. Compounds promoting the activity of the above polypeptide or the expression of the above DNA are useful as preventives/remedies for diseases such as rheumatoid arthritis, arthrosis deformans, osteoporosis, bone fracture and cancer. Compounds inhibiting the activity of the above polypeptide or the expression of the above DNA are useful as preventives/remedies for diseases such as intervertebral disk hernia, ischiodynia and etopic chondrogenesis.