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1. (WO2001038332) GAMMA-HYDROXY-2-(FLUOROALKYLAMINOCARBONYL)-1-PIPERAZINEPENTANAMIDES AS HIV PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/038332 International Application No.: PCT/US2000/032089
Publication Date: 31.05.2001 International Filing Date: 21.11.2000
Chapter 2 Demand Filed: 19.06.2001
IPC:
A61K 31/00 (2006.01) ,A61K 45/06 (2006.01) ,C07D 401/06 (2006.01) ,C07D 405/06 (2006.01) ,C07D 405/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 417/14 (2006.01) ,C07D 491/04 (2006.01) ,C07D 495/04 (2006.01)
Applicants: TATA, James, R.[US/US]; US (UsOnly)
CHAPMAN, Kevin, T.[US/US]; US (UsOnly)
DUFFY, Joseph, Leslie[US/US]; US (UsOnly)
KEVIN, Nancy, J.[US/US]; US (UsOnly)
CHENG, Yuan[US/US]; US (UsOnly)
RANO, Thomas, A.[US/US]; US (UsOnly)
ZHANG, Fengqi[CN/US]; US (UsOnly)
HUENING, Tracy[US/US]; US (UsOnly)
KIRK, Brian, Anthony[US/US]; US (UsOnly)
LU, Zhijian[US/US]; US (UsOnly)
RAGHAVAN, Subharekha[IN/US]; US (UsOnly)
FLEITZ, Fred, J.[US/US]; US (UsOnly)
PETRILLO, Daniel, E.[US/US]; US (UsOnly)
ARMSTRONG, Joseph, D., III[US/US]; US (UsOnly)
VARSOLONA, Richard, J.[US/US]; US (UsOnly)
ASKIN, David[US/US]; US (UsOnly)
HOERRNER, R., Scott[US/US]; US (UsOnly)
PURICK, Robert[US/US]; US (UsOnly)
MERCK & CO., INC.[US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US (AllExceptUS)
Inventors: TATA, James, R.; US
CHAPMAN, Kevin, T.; US
DUFFY, Joseph, Leslie; US
KEVIN, Nancy, J.; US
CHENG, Yuan; US
RANO, Thomas, A.; US
ZHANG, Fengqi; US
HUENING, Tracy; US
KIRK, Brian, Anthony; US
LU, Zhijian; US
RAGHAVAN, Subharekha; US
FLEITZ, Fred, J.; US
PETRILLO, Daniel, E.; US
ARMSTRONG, Joseph, D., III; US
VARSOLONA, Richard, J.; US
ASKIN, David; US
HOERRNER, R., Scott; US
PURICK, Robert; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US
Priority Data:
60/167,47824.11.1999US
60/177,05320.01.2000US
Title (EN) GAMMA-HYDROXY-2-(FLUOROALKYLAMINOCARBONYL)-1-PIPERAZINEPENTANAMIDES AS HIV PROTEASE INHIBITORS
(FR) GAMMA-HYDROXY-2-(FLUOROALKYLAMINOCARBONYL)-1-PIPERAZINEPENTANAMIDES INTERVENANT COMME INHIBITEURS DE LA PROTEASE DU VIH
Abstract:
(EN) $g(g)-(Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.
(FR) Les composés $g(g)(-hydroxy-2-(fluoroalkylaminocarbonyl)-1-pipérazinepentanamide sont des inhibiteurs de la protéase du VIH et des inhibiteurs de la réplication du VIH. Ces composés jouent un rôle utile dans la prévention ou le traitement de l'infection par VIH et le traitement du SIDA, sous forme de composés, de sels pharmaceutiquement acceptables, de compositions pharmaceutiques, utilisés tels quels ou combinés à d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. Sont également décrites des méthodes de traitement du SIDA et de prévention ou de traitement de l'infection par le VIH. Les composés selon l'invention sont efficaces contre les mutants viraux qui sont résistant aux inhibiteurs de la protéase du VIH actuellement utilisés dans le traitement du SIDA et de l'infection par le VIH.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)