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1. (WO2001037869) VACCINE COMPOSITIONS

Pub. No.:    WO/2001/037869    International Application No.:    PCT/AU2000/001410
Publication Date: Fri Jun 01 01:59:59 CEST 2001 International Filing Date: Sat Nov 18 00:59:59 CET 2000
IPC: A61K 39/29
Applicants: CSL LIMITED
CHIRON CORPORATION
Inventors: DRANE, Debbie
COX, John
HOUGHTON, Michael
PALIARD, Xavier
Title: VACCINE COMPOSITIONS
Abstract:
The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.