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1. (WO2001037869) VACCINE COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/037869    International Application No.:    PCT/AU2000/001410
Publication Date: 31.05.2001 International Filing Date: 17.11.2000
Chapter 2 Demand Filed:    17.05.2001    
IPC:
A61K 39/29 (2006.01)
Applicants: CSL LIMITED [AU/AU]; 45 Poplar Road, Parkville, VIC 3052 (AU).
CHIRON CORPORATION [US/US]; 4560 Horton Street, Emeryville, CA 94608-2916 (US)
Inventors: DRANE, Debbie; (AU).
COX, John; (AU).
HOUGHTON, Michael; (US).
PALIARD, Xavier; (US)
Agent: SLATTERY, John, M.; Davies Collison Cave, 1 Little Collins Street, Melbourne, VIC 3000 (AU)
Priority Data:
60/166,652 19.11.1999 US
60/224,362 11.08.2000 US
Title (EN) VACCINE COMPOSITIONS
(FR) COMPOSITIONS VACCINALES
Abstract: front page image
(EN)The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.
(FR)L'invention concerne généralement un complexe immunogénique comprenant un véhicule organique chargé et un antigène chargé et, notamment un véhicule organique à charge négative et un antigène à charge positive, l'antigène chargé étant une polyprotéine du virus de l'Hépatite C (VHC), particulièrement la protéine noyau de VHC ou un fragment de celui-ci, ou une protéine de fusion comprenant ladite polyprotéine ou un fragment de celle-ci. Les complexes de l'invention sont utiles, entre autres, dans des compositions vaccinales, en tant qu'agents thérapeutiques et/ou prophylactiques, pour faciliter l'induction de réponses immunitaires, et notamment une réponse des cellules T cytotoxiques, dans le traitement d'un état pathologique résultant d'une infection à VHC.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)