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1. (WO2001037861) A CONJUGATE OF A COLLAGEN II-BINDING FRAGMENT AND AN ARTHRITIS-AFFECTING PHARMACEUTICAL SUBSTANCE

Pub. No.:    WO/2001/037861    International Application No.:    PCT/SE2000/002293
Publication Date: Fri Jun 01 01:59:59 CEST 2001 International Filing Date: Thu Nov 23 00:59:59 CET 2000
IPC: A61K 38/00
C07K 14/78
C07K 14/81
Applicants: ANAMAR MEDICAL AB
HEINEGÅRD, Dick
MåNSSON, Bengt
Inventors: HEINEGÅRD, Dick
MåNSSON, Bengt
Title: A CONJUGATE OF A COLLAGEN II-BINDING FRAGMENT AND AN ARTHRITIS-AFFECTING PHARMACEUTICAL SUBSTANCE
Abstract:
The invention provides a conjugate of a collagen II-binding chondroadherin fragment and an arthritis-affecting pharmaceutical substance, such as a cytokine, a cytokine antagonist and/or a protease inhibitor. It has turned out that chondroadherin specifically interacts with collagen II thereby forming a complex. Release of cartilage extracellular matrix components, such as chondroadherin and collagen II is a symptom of arthitis. By providing a conjugate according to the present invention it is therefore possible to direct arthitis-affecting pharmaceutical substances directly to the pathogenic tissue. The inventive conjugate can be manufactured by chemical crosslinking. In case the arthitis-affecting pharmaceutical substance is a protein or a peptide, the conjugate can be a fusion protein and be produced by genetic engineering techniques.