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1. (WO2001037854) METHOD FOR TREATMENT AND PREVENTION OF PHYSIOLOGICAL SHOCK

Pub. No.:    WO/2001/037854    International Application No.:    PCT/US2000/032179
Publication Date: Fri Jun 01 01:59:59 CEST 2001 International Filing Date: Thu Nov 23 00:59:59 CET 2000
IPC: A61K 31/00
A61K 31/24
A61K 31/245
A61K 38/06
A61K 38/55
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
THE SCRIPPS RESEARCH INSTITUTE
SCHMID-SCHOENBEIN, Geert
HUGLI, Tony, E.
MITSUOKA, Hiroshi
Inventors: SCHMID-SCHOENBEIN, Geert
HUGLI, Tony, E.
MITSUOKA, Hiroshi
Title: METHOD FOR TREATMENT AND PREVENTION OF PHYSIOLOGICAL SHOCK
Abstract:
Shock is a life threatening complication in situations associated with trauma including burns, surgery, ischemia, sepsis, and other critical care applications. Shock is induced by pancreatic proteases when they are released into the small intestine when the tissue is compromised due to trauma. Administration of protease inhibitors into the small intestine, either orally, intraveneously, or by direct lavage, was demonstrated to prevent shock in rats as determined by both survival time and molecular and histological analysis.