Search International and National Patent Collections

1. (WO2001037820) IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS

Pub. No.:    WO/2001/037820    International Application No.:    PCT/US2000/032277
Publication Date: Fri Jun 01 01:59:59 CEST 2001 International Filing Date: Thu Nov 23 00:59:59 CET 2000
IPC: A61K 9/20
A61K 9/48
A61K 31/404
A61K 31/415
A61K 31/454
A61K 31/497
A61K 31/5377
A61K 47/02
A61K 47/10
A61K 47/44
Applicants: SUGEN, INC.
SHENOY, Narmada
SORASUCHART, Waranush
KOPARKAR, Arun
Inventors: SHENOY, Narmada
SORASUCHART, Waranush
KOPARKAR, Arun
Title: IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS
Abstract:
The present invention features formulations of indolinones which compounds are ionizable as free acids or free bases. The formulation is suitable for parenteral or oral administration, wherein the formulation comprises an ionizable substituted indolinone, and a pharmaceutically acceptable carrier therefor. The term 'ionizable substituted indolinone' includes pyrrole substituted 2-indolinones which, in addition to being otherwise optionally substituted on both the pyrrole and 2-indolinone portions of the compound, are necessarily substituted on the pyrrole moiety with one or more hydrocarbon chains which themselves are substituted with at least one polar group. The formulations and the compounds themselves are useful for the treatment of protein kinase related disorders as discussed herein.