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1. (WO2001037820) IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/037820    International Application No.:    PCT/US2000/032277
Publication Date: 31.05.2001 International Filing Date: 22.11.2000
Chapter 2 Demand Filed:    22.06.2001    
IPC:
A61K 9/20 (2006.01), A61K 9/48 (2006.01), A61K 31/404 (2006.01), A61K 31/415 (2006.01), A61K 31/454 (2006.01), A61K 31/497 (2006.01), A61K 31/5377 (2006.01), A61K 47/02 (2006.01), A61K 47/10 (2006.01), A61K 47/44 (2006.01)
Applicants: SUGEN, INC. [US/US]; 230 East Grand Avenue, South San Francisco, CA 94080-4811 (US) (For All Designated States Except US).
SHENOY, Narmada [IN/US]; (US) (For US Only).
SORASUCHART, Waranush [TH/TH]; (TH) (For US Only).
KOPARKAR, Arun [US/US]; (US) (For US Only)
Inventors: SHENOY, Narmada; (US).
SORASUCHART, Waranush; (TH).
KOPARKAR, Arun; (US)
Agent: BURROUS, Beth, A.; Foley & Lardner, 3000 K. Street, N.W., Suite 500, Washington, DC 20007 (US)
Priority Data:
60/167,544 24.11.1999 US
Title (EN) IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS
(FR) FORMULATIONS POUR AGENTS PHARMACEUTIQUES IONISABLES COMME ACIDES LIBRES OU BASES LIBRES
Abstract: front page image
(EN)The present invention features formulations of indolinones which compounds are ionizable as free acids or free bases. The formulation is suitable for parenteral or oral administration, wherein the formulation comprises an ionizable substituted indolinone, and a pharmaceutically acceptable carrier therefor. The term 'ionizable substituted indolinone' includes pyrrole substituted 2-indolinones which, in addition to being otherwise optionally substituted on both the pyrrole and 2-indolinone portions of the compound, are necessarily substituted on the pyrrole moiety with one or more hydrocarbon chains which themselves are substituted with at least one polar group. The formulations and the compounds themselves are useful for the treatment of protein kinase related disorders as discussed herein.
(FR)L'invention concerne des formulations d'indolinones ionisables comme acides libres ou bases libres. La formulation convient pour une administration parentérale ou orale. La formulation contient une indolinone substituée ionisable et un excipient pharmaceutiquement acceptable. Le terme « indolinone substituée ionisable » comprend des 2-indolinones substituées en pyrrole qui, outre qu'elles peuvent être éventuellement substituées sur les parties pyrrole et 2-indolinone du composé, sont substituées obligatoirement sur la fraction pyrrole par une ou plusieurs chaînes hydrocarbonées, qui sont elles-mêmes substituées par au moins un groupe polaire. Les formulations et les composés de l'invention sont utiles dans le traitement d'affections liées à la protéine kinase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)