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1. (WO2001036666) APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/036666 International Application No.: PCT/US2000/031158
Publication Date: 25.05.2001 International Filing Date: 15.11.2000
Chapter 2 Demand Filed: 13.06.2001
IPC:
C12Q 1/56 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
56
involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
Applicants:
i-STAT CORPORATION [US/US]; 104 East Windsor Center Drive East Windsor, NJ 08520, US
Inventors:
Agent:
KAY, Christopher, J. ; Pepper Hamilton, LLP 600 Fourteenth Street, NW Washington, DC 20005-2004, US
Priority Data:
60/164,93515.11.1999US
Title (EN) APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES
(FR) APPAREIL ET PROCEDE POUR FAIRE DES DOSAGES DE COAGULATION DANS DES ECHANTILLONS LIQUIDES
Abstract:
(EN) This invention is a disposable cartridge (10) for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge (10), in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor (29) also housed within the cartridge (10) which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
(FR) L'invention se présente comme une cartouche jetable (10) utilisée du côté patient pour effectuer des dosages de coagulation traditionnels sur du sang frais entier ou des échantillons dérivés du sang. La cartouche (10), utilisée avec un analyseur électronique, permet de mesurer un échantillon liquide et de le mélanger quantitativement avec des réactifs qui actionnent la cascade de coagulation. L'invention concerne aussi un substrat artificiel pour la thrombine, l'enzyme dont l'action consiste à former des caillots. Elle permet de détecter la formation de caillots au moyen d'un capteur microfabriqué (29) également monté à l'intérieur de la cartouche (10), qui détecte par procédé électrochimique le produit de la réaction de la thrombine sur le substrat synthétique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)