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1. (WO2001036641) DOUBLE-STRANDED RNA RECEPTOR (dsRNA-R) AND METHODS RELATING THERETO

Pub. No.:    WO/2001/036641    International Application No.:    PCT/US2000/041726
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Thu Nov 02 00:59:59 CET 2000
IPC: C07K 14/705
Applicants: CHIRON CORPORATION
MACKICHAN, Mary, Lee
Inventors: MACKICHAN, Mary, Lee
Title: DOUBLE-STRANDED RNA RECEPTOR (dsRNA-R) AND METHODS RELATING THERETO
Abstract:
The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response and the methods of identifying compounds which bind to and/or modulate dsRNA-R.