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1. (WO2001036640) HUMAN FGF-21 GENE AND GENE EXPRESSION PRODUCTS

Pub. No.:    WO/2001/036640    International Application No.:    PCT/US2000/031745
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Fri Nov 17 00:59:59 CET 2000
IPC: C07K 14/50
Applicants: CHIRON CORPORATION
KYOTO UNIVERSITY
Inventors: ITOH, Nobuyuki
KAVANAUGH, W., Michael
Title: HUMAN FGF-21 GENE AND GENE EXPRESSION PRODUCTS
Abstract:
This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.