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Machine translation
1. (WO2001036611) PROCESS FOR THE PRODUCTION OF A REVERSIBLY INACTIVE ACIDIFIED PLASMIN COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/036611 International Application No.: PCT/US2000/042143
Publication Date: 25.05.2001 International Filing Date: 13.11.2000
Chapter 2 Demand Filed: 16.03.2001
IPC:
A61K 38/00 (2006.01) ,A61K 38/48 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/18 (2006.01) ,A61K 47/26 (2006.01) ,C12N 9/68 (2006.01)
Applicants: DADD, Christopher[US/US]; US (UsOnly)
STENLAND, Christopher, J.[US/US]; US (UsOnly)
KENT, Jonathan, D.[US/US]; US (UsOnly)
KORNEYEVA, Marina, N.[RU/US]; US (UsOnly)
BAUMBACH, George, A.[US/US]; US (UsOnly)
COOK, Scott, A.[US/US]; US (UsOnly)
BRADLEY, Rita, T.[US/US]; US (UsOnly)
NOVOKHATNY, Valery[UA/US]; US (UsOnly)
VILLINES, Tanette, B.[US/US]; US (UsOnly)
BAYER CORPORATION[US/US]; 100 Bayer Road Pittsburgh, PA 15205, US (AllExceptUS)
Inventors: DADD, Christopher; US
STENLAND, Christopher, J.; US
KENT, Jonathan, D.; US
KORNEYEVA, Marina, N.; US
BAUMBACH, George, A.; US
COOK, Scott, A.; US
BRADLEY, Rita, T.; US
NOVOKHATNY, Valery; US
VILLINES, Tanette, B.; US
Agent: MASSEY, Carl, B., Jr.; Womble Carlyle Sandridge & Rice, PLLC Post Office Box 7037 Atlanta, GA 30357-0037, US
Priority Data:
09/438,33113.11.1999US
Title (EN) PROCESS FOR THE PRODUCTION OF A REVERSIBLY INACTIVE ACIDIFIED PLASMIN COMPOSITION
(FR) PROCEDE DE PRODUCTION D'UNE COMPOSITION DE PLASMINE ACIDIFIEE INACTIVEE DE MANIERE REVERSIBLE
Abstract: front page image
(EN) Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The purified plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II + III chromatographic process and eluded at a low pH. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
(FR) L'invention concerne un procédé de production d'une plasmine acidifiée inactivée de manière réversible par activation du plasminogène ainsi qu'un procédé de production d'un plasminogène purifié. La plasmine est isolée et stockée avec un agent à faible capacité de tamponnage du pH afin d'obtenir une formulation sensiblement stable. Ce plasminogène purifié est généralement purifié d'une fraction obtenue dans le séparation de l'immunoglobuline de la fraction II + III par un procédé chromatographique et il subit une élution à un faible pH. La plasmine acidifiée inactivée de manière réversible peut être utilisée dans l'administration d'une thérapie thrombolytique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)