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1. (WO2001036610) HUMAN ENZYMES OF THE METALLOPROTEASE FAMILY

Pub. No.:    WO/2001/036610    International Application No.:    PCT/EP2000/011532
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Sat Nov 18 00:59:59 CET 2000
IPC: C12N 9/64
Applicants: SOLVAY PHARMACEUTICALS B.V.
DELEERSNIJDER, Willy
WIEGERS, Rico
WESKE, Michael
Inventors: DELEERSNIJDER, Willy
WIEGERS, Rico
WESKE, Michael
Title: HUMAN ENZYMES OF THE METALLOPROTEASE FAMILY
Abstract:
This invention relates to newly identified, polypeptides and polynucleotides encoding such polypeptides, which hereinafter are referred to as IGS5, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides. The polypeptides and polynucleotides are related to the metalloprotease family and preferably of human type. The invention also relates to inhibiting or stimulating/activating the action of such polypeptides and polynucleotides, to a vector containing said polynucleotides and to a host cell containing such vector. The invention further relates to a method for screening compounds capable to act as a stimulator or inhibitor of said IGS5 enzyme. The Polypeptides of the present invention are of interest in the context of several dysfunctions, disorders or diseases. The Polypeptides of the present invention are in particular of interest in the context of cardiovascular diseases.