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1. (WO2001036609) METHOD OF THROMBOLYSIS BY LOCAL DELIVERY OF REVERSIBLY INACTIVATED ACIDIFIED PLASMIN

Pub. No.:    WO/2001/036609    International Application No.:    PCT/US2000/031115
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Tue Nov 14 00:59:59 CET 2000
IPC: A61K 38/00
A61K 38/48
A61K 47/02
A61K 47/12
A61K 47/18
A61K 47/26
C12N 9/68
Applicants: BAYER CORPORATION
NOVOKHATNY, Valery, B.
JESMOK, Gary, J.
LANDSKRONER, Kyle, A.
TAYLOR, Kathryn, K.
ZIMMERMAN, Thomas, P.
Inventors: NOVOKHATNY, Valery, B.
JESMOK, Gary, J.
LANDSKRONER, Kyle, A.
TAYLOR, Kathryn, K.
ZIMMERMAN, Thomas, P.
Title: METHOD OF THROMBOLYSIS BY LOCAL DELIVERY OF REVERSIBLY INACTIVATED ACIDIFIED PLASMIN
Abstract:
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic occlusion are disclosed. Further disclosed is a method for administering a therapeutic dose of a fibrinolytic composition substantially free of plasminogen activator to a human or animal having a vascular thrombotic occlusion. The fibrinolytic composition includes a reversibly inactivated acidified plasmin substantially free of plasminogen activator. Intravascular catheter delivery of the fibrinolytic composition directly into or in the immediate vicinity of the thrombus is disclosed to minimize the systemic degradation of fibrin while retaining the maximum plasmin activity against the thrombus.