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1. (WO2001036608) REVERSIBLY INACTIVATED ACIDIFIED PLASMIN

Pub. No.:    WO/2001/036608    International Application No.:    PCT/US2000/031090
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Tue Nov 14 00:59:59 CET 2000
IPC: A61K 38/00
A61K 38/48
A61K 47/02
A61K 47/12
A61K 47/18
A61K 47/26
C12N 9/68
Applicants: BAYER CORPORATION
ZIMMERMAN, Thomas, P.
NOVOKHATNY, Valery
JIANG, Shan
COLANDENE, James
Inventors: ZIMMERMAN, Thomas, P.
NOVOKHATNY, Valery
JIANG, Shan
COLANDENE, James
Title: REVERSIBLY INACTIVATED ACIDIFIED PLASMIN
Abstract:
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.