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Machine translation
1. (WO2001036599) MICROPARTICLE-BASED TRANSFECTION AND ACTIVATION OF DENDRITIC CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/036599    International Application No.:    PCT/US2000/031776
Publication Date: 25.05.2001 International Filing Date: 17.11.2000
Chapter 2 Demand Filed:    16.06.2001    
IPC:
A61K 48/00 (2006.01), C12N 15/88 (2006.01)
Applicants: CHIRON CORPORATION [US/US]; 4560 Horton St., Emeryville, CA 94608 (US)
Inventors: DONNELLY, John, James; (US).
DENIS-MIZE, Kimberly, Sue; (US).
OTT, Gary, Steven; (US)
Priority Data:
60/166,514 19.11.1999 US
Title (EN) MICROPARTICLE-BASED TRANSFECTION AND ACTIVATION OF DENDRITIC CELLS
(FR) TRANSFECTION ET ACTIVATION DE CELLULES DENDRITIQUES AU MOYEN DE MICROPARTICULES
Abstract: front page image
(EN)The present invention provides an effective method for the transfection of dendritic cells by non-viral methods. The present invention provides this benefit by incubating dendritic cells and a specified transfection agent. The transfection agent comprises a polynucleotide and microparticles, with the microparticles being comprised of biodegradable polymer and cationic detergent. The dendritic cells and transfection agent are incubated for a time sufficient to transfect the dendritic cells with the polynucleotide.
(FR)L'invention concerne un procédé efficace de transfection de cellules dendritiques par des méthodes non-virales. On atteint cet objectif en incubant des cellules dendritiques avec un agent de transfection particulier. Cet agent de transfection comprend un polynucléotide et des microparticules, ces dernières étant composées d'un polymère biodégradable et d'un détergent cationique. On incube les cellules dendritiques et l'agent de transfection pendant une durée suffisante pour transfecter les cellules dendritiques avec le polynucléotide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)