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1. (WO2001036589) HUMAN EX VIVO IMMUNE SYSTEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/036589    International Application No.:    PCT/US2000/031747
Publication Date: 25.05.2001 International Filing Date: 17.11.2000
Chapter 2 Demand Filed:    12.06.2001    
IPC:
G01N 33/50 (2006.01), A61K 48/00 (2006.01), A61P 37/00 (2006.01), C07K 16/00 (2006.01), C12M 3/06 (2006.01), C12N 15/09 (2006.01), C12N 5/02 (2006.01), C12N 5/0789 (2010.01), C12P 21/08 (2006.01), C12Q 1/68 (2006.01), G01N 33/15 (2006.01), G01N 33/569 (2006.01)
Applicants: UNIVERSITY OF ROCHESTER [US/US]; 518 Hylan Building Rochester, NY 14627 (US)
Inventors: WU, J., H., David; (US).
MANTALARIS, Athanassios; (US)
Agent: GOLDMAN, Michael, L.; Nixon Peabody LLP Clinton Square P.O. Box 31051 Rochester, NY 14603 (US)
Priority Data:
60/166,026 17.11.1999 US
Title (EN) HUMAN EX VIVO IMMUNE SYSTEM
(FR) SYSTEME IMMUNITAIRE HUMAIN EX VIVO
Abstract: front page image
(EN)The present invention provides cultured immune system cells and methods of producing same. The method comprises culturing stromal cells and hemopoietic stem cells or in a chamber having a scaffolding covered or surrounded with culture medium, wherein the scaffolding allows for hemopoietic stem cells and stromal cells to have cell to cell contacts in three dimensions. The subject immune system cells are useful for screening drugs which inhibit or stimulate the immune system. The subject immune system cells are also useful in treating diseases of the immune system.
(FR)La présente invention concerne des cellules du système immunitaire mises en culture et leurs procédés de production. Le procédé consiste à mettre en culture des cellules de stroma et des cellules souches hématopoïétiques soit dans une chambre dotée d'une structure tridimensionnelle recouverte ou entourée d'un milieu de culture, cette structure permettant aux cellules souches hématopoïétiques et aux cellules de stroma d'avoir des contacts cellule à cellule en trois dimensions. Lesdites cellules du système immunitaire sont utiles pour le dosage de médicaments qui inhibent ou stimulent le système immunitaire. Elles sont également utiles dans le traitement de certaines maladies du système immunitaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)