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1. (WO2001036416) NOVEL THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/036416 International Application No.: PCT/ES2000/000432
Publication Date: 25.05.2001 International Filing Date: 15.11.2000
Chapter 2 Demand Filed: 14.06.2001
IPC:
C07D 417/12 (2006.01) ,C07D 473/34 (2006.01) ,C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants: MOURELLE MANCINI, Marisabel[ES/ES]; ES (UsOnly)
DEL CASTILLO NIETO, Juan Carlos[ES/ES]; ES (UsOnly)
DE RAMON AMAT, Elisabet[ES/ES]; ES (UsOnly)
VITA-INVEST, S. A.[ES/ES]; C. Fontsanta, 12-14 E-08970 Sant Joan Despi, ES (AllExceptUS)
Inventors: MOURELLE MANCINI, Marisabel; ES
DEL CASTILLO NIETO, Juan Carlos; ES
DE RAMON AMAT, Elisabet; ES
Agent: PONTI SALES, Adelaida ; C. Consell de Cent, 322 E-08007 Barcelona, ES
Priority Data:
P 990253318.11.1999ES
Title (EN) NOVEL THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS
(FR) NOUVEAUX DERIVES DE THIAZOLIDINDIONE UTILISES COMME AGENTS ANTIDIABETIQUES
(ES) NUEVOS DERIVADOS DE TIAZOLIDINDIONA COMO AGENTES ANTIDIABETICOS
Abstract:
(EN) The invention relates to compounds of general formula (I), to their possible pharmaceutically acceptable salts and tautomeric forms. The invention also relates to a method for obtaining said compounds and to their utilization as antidiabetic and hypolipidemic agents, by themselves or combined with other antidiabetic agents such as sulfonylureas or biguanides, as well as to their utilization in the treatment of complications associated with insulin resistance such as hypertension, hyperuricemia or other cardiovascular, metabolic and endocrine disorders or other disorders associated with diabetes.
(FR) La présente invention concerne des composés représentés par la formule générale (I), leurs éventuels sels acceptables d'un point de vue pharmaceutiques et formes tautomères. La présente invention concerne également un procédé de préparation et d'utilisation desdits composés comme antidiabétiques et hypolipémiants, seuls ou en combinaison avec d'autres agents antidiabétiques comme les sulfonylurées ou les biguanides, ainsi que dans le traitement des complications associées à la résistance à l'insuline, telles que l'hypertension, l'hyperuricémie ou d'autres troubles cardio-vasculaires, métaboliques, endocriniens, ou d'autres associés au diabète.
(ES) La presente invención se refiere a compuestos de fórmula general (I), a sus posibles sales farmacéuticamente aceptables y formas tautómeras. La presente invención también se refiere a un procedimiento para su obtención y a su uso como antidiabéticos e hipolipemiantes, solos o en combinación con otros agentes antidiabéticos como las sulfonilureas o biguanidas, así como para el tratamiento de complicaciones asociadas a la resistencia a la insulina, tales como hipertensión, hiperuricemia u otros trastornos cardiovasculares, metabólicos, endocrinos, u otros relacionados con la diabetes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)