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Machine translation
1. (WO2001036392) [5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/036392    International Application No.:    PCT/JP2000/007854
Publication Date: 25.05.2001 International Filing Date: 09.11.2000
Chapter 2 Demand Filed:    09.11.2000    
IPC:
C07D 239/42 (2006.01)
Applicants: DAINIPPON PHARMACEUTICAL CO., LTD. [JP/JP]; 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8524 (JP) (For All Designated States Except US).
MURATA, Teruya [JP/JP]; (JP) (For US Only).
OHNO, Kazunori [JP/JP]; (JP) (For US Only).
TANAKA, Masayasu [JP/JP]; (JP) (For US Only).
ITOH, Mari [JP/JP]; (JP) (For US Only)
Inventors: MURATA, Teruya; (JP).
OHNO, Kazunori; (JP).
TANAKA, Masayasu; (JP).
ITOH, Mari; (JP)
Agent: AOYAMA, Tamotsu; Aoyama & Partners, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 540-0001 (JP)
Priority Data:
11/326290 17.11.1999 JP
Title (EN) [5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATE OF THESE COMPOUNDS
(FR) DERIVES DE [5-CHLORO-6-PHENYL-2-(4-TRIFLUOROMETHYLPHENYL)-4-PYRIMIDINYLAMINO]ACETAMIDE, PROCEDE DE PRODUCTION DESDITS COMPOSES, COMPOSITIONS MEDICINALES CONTENANT CES COMPOSES ET PRODUIT INTERMEDIAIRE DE CES COMPOSES
Abstract: front page image
(EN)5-Chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinylamino]acetamide derivatives represented by general formula (I). Because of having a potent antirheumatic effect and a low toxicity, these compounds are useful as remedies and preventives for rheumatic diseases such as rheumatism, Becet's disease and ankylosing spondylitis, and inflammatory immunologic diseases such as multiple screlosis, systemic lupus erythematosus and inflammatory autoimmunologic diseases such as Sjoegren's syndrome. In said formula, R1 represents methyl or cyclopropyl.
(FR)L'invention concerne des dérivés de [5-chloro-6-phényl-2-(4-trifluorométhylphényl)-4-pyrimidinylamino]acétamide représentés par la formule générale (I). Du fait de leur puissant effet antirhumatismal et de leur faible toxicité, ces composés peuvent être utilisés comme agents thérapeutiques ou comme agents de prévention contre les maladies rhumatismales telles que le rhumatisme, la maladie de Becet et la spondylarthrite ankylosante, et contre les maladies immunologiques inflammatoires telles que la sclérose en plaques, le lupus érythémateux disséminé et les maladies auto-immunes inflammatoires (syndrome de Sjögren, par exemple). Dans la formule générale (I), R1 représente méthyle ou cyclopropyle.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)