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1. (WO2001036376) NOVEL PHENYLALANINE DERIVATIVES

Pub. No.:    WO/2001/036376    International Application No.:    PCT/JP2000/008152
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Tue Nov 21 00:59:59 CET 2000
IPC: C07C 235/74
C07C 275/42
C07C 311/08
C07C 311/10
C07C 311/13
C07C 311/16
C07C 311/21
C07C 311/29
C07C 311/44
C07C 317/44
C07C 323/25
C07C 323/60
C07C 323/62
C07C 335/22
C07D 207/12
C07D 207/14
C07D 207/16
C07D 239/38
C07D 239/42
C07D 295/185
Applicants: AJINOMOTO CO., INC.

TANAKA, Yasuhiro

YOSHIMURA, Toshihiko

IZAWA, Hiroyuki

EJIMA, Chieko

KOJIMA, Mitsuhiko

SATAKE, Yuko

NAKANISHI, Eiji

SUZUKI, Nobuyasu

MAKINO, Shingo

SUZUKI, Manabu

MURATA, Masahiro

Inventors: TANAKA, Yasuhiro

YOSHIMURA, Toshihiko

IZAWA, Hiroyuki

EJIMA, Chieko

KOJIMA, Mitsuhiko

SATAKE, Yuko

NAKANISHI, Eiji

SUZUKI, Nobuyasu

MAKINO, Shingo

SUZUKI, Manabu

MURATA, Masahiro

Title: NOVEL PHENYLALANINE DERIVATIVES
Abstract:
Phenylalanine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof: wherein x represents an interatomic bond, -O-, etc.; Y and Z represent each -C(=O)-, etc.; A represents a specific substituted phenyl group, a specific nitrogen-containing heterocycle, etc.; C represents hydrogen, alkly, etc.; D and E represent each alkyl or D and E may be bonded to each other to form a ring, etc.; F and G represent each hydrogen or alkyl, or F and G may be bonded to each otherto form a ring, etc.; n is from 0 to 2; K represents OR7, NR7R8, R7, etc.; and J and J' represent each hydrogen, halogeno, etc. These derivatives and analogs thereof show an α 4 integlin inhibitory activity and are usable as remedies for various diseases relating to α 4 integlin.