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1. (WO2001035986) METHODS AND COMPOSITIONS FOR MODULATING ER-STRESS-INDUCED CHOLESTEROL ACCUMULATION

Pub. No.:    WO/2001/035986    International Application No.:    PCT/CA2000/001372
Publication Date: Sat May 26 01:59:59 CEST 2001 International Filing Date: Fri Nov 17 00:59:59 CET 2000
IPC: A61K 38/20
G01N 33/92
Applicants: HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT INC.
AUSTIN, Richard, C.
WERSTUCK, Geoff
Inventors: AUSTIN, Richard, C.
WERSTUCK, Geoff
Title: METHODS AND COMPOSITIONS FOR MODULATING ER-STRESS-INDUCED CHOLESTEROL ACCUMULATION
Abstract:
The present invention provides methods for preventing the accumulation of cholesterol/triglycerides within mammalian cells. The present methods are based upon the surprising discovery that ER stress in a cell leads to cholesterol/triglyceride accumulation within the cell, which cholesterol/triglyceride accumulation is often a causative factor in the development of any of a number of conditions or diseases, such as atherosclerosis. The ER stress can be the result of any of a variety of causes, including homocysteine, viral infection, and hypoxia. Accordingly, counteracting the progression or the severity of ER stress can be used to inhibit the accumulation of cholesterol/triglycerides in said cell, thereby preventing or lessening the severity of any of a number of cholesterol-related diseases or conditions, e.g., atherosclerosis. In addition, the presence of ER stress in a cell can be used to diagnose a cholesterol associated disease, or to predict the propensity of a mammal to develop a disease.