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1. (WO2001035092) ESTRIOL MONITORING OF MATERNAL BLOOD FOR ANTENATAL STEROID ACCELERATION OF FETAL LUNG MATURATION

Pub. No.:    WO/2001/035092    International Application No.:    PCT/US1999/026053
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Sat Nov 06 00:59:59 CET 1999
IPC: G01N 33/49
G01N 33/74
Applicants: PROBIOTIX, INC.
TORDAY, John, S.
Inventors: TORDAY, John, S.
Title: ESTRIOL MONITORING OF MATERNAL BLOOD FOR ANTENATAL STEROID ACCELERATION OF FETAL LUNG MATURATION
Abstract:
Maternal blood unconjugated estriol is used to determine whether steroid treatment has or has not effectively accelerated fetal lung maturation and reduced the risk of RDS. A blood sample is obtained from the mother prior to treating her with steroids and again 24 hours later. The blood cells are separated from the serum and the serum is analyzed for unconjugated estriol concentration in the two blood samples obtained. If the percent change in the estriol concentration of the mother's blood decreases by a significant percentage over the 24 hour period from the start of the steroid treatment, the infant will not develop RDS. If the percent change in the estriol concentration of the mother's blood does not decrease by a significant percentage over the 24 hour period from the start of the steroid treatment, the infant will be at the same risk of RDS as it would have been without the steroid treatment. The information obtained from this test is used to make decisions regarding further treatment.