Search International and National Patent Collections

1. (WO2001034788) IN-VITRO ASSAY FOR ASSESSMENT OF CYTOTOXICITY OF A CANDIDATE AGENT

Pub. No.:    WO/2001/034788    International Application No.:    PCT/IL2000/000730
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Thu Nov 09 00:59:59 CET 2000
IPC: G01N 33/50
Applicants: YOREH BIOTECHNOLOGIES LTD.
JEHUDA-COHEN, Tamar
Inventors: JEHUDA-COHEN, Tamar
Title: IN-VITRO ASSAY FOR ASSESSMENT OF CYTOTOXICITY OF A CANDIDATE AGENT
Abstract:
This invention provides an in-vitro assay method of assessing cytotoxicity of an agent, comprising the following steps: a) obtaining a sample; b) culturing the sample in the presence of a mitogen so as to induce polyclonal and specific activation of lymphocytic cells leading to antibody production; c) contacting the culture of step b) with the agent; d) detecting the level of the antibody in the sample, e) comparing the level of the antibody in the sample, wherein if the level of the antibody in step d) is less than a control level the agent is cytotoxic, thereby assessing the cytotoxicity of an agent.