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1. (WO2001034785) NOVEL METALLOPROTEASE HAVING AGGRECANASE ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/034785 International Application No.: PCT/JP2000/007917
Publication Date: 17.05.2001 International Filing Date: 10.11.2000
Chapter 2 Demand Filed: 11.05.2001
IPC:
A61K 38/00 (2006.01) ,C12N 9/64 (2006.01)
Applicants: YAMAJI, Noboru[JP/JP]; JP (UsOnly)
NISHIMURA, Kouichi[JP/JP]; JP (UsOnly)
ABE, Kunitake[JP/JP]; JP (UsOnly)
OHARA, Osamu[JP/JP]; JP (UsOnly)
NAGASE, Takahiro[JP/JP]; JP (UsOnly)
NOMURA, Nobuo[JP/JP]; JP (UsOnly)
YAMANOUCHI PHARMACEUTICAL CO., LTD.[JP/JP]; 3-11, Nihonbashi-Honcho 2-chome Chuo-ku, Tokyo 103-8411, JP (AllExceptUS)
KAZUSA DNA RESEARCH INSTITUTE[JP/JP]; 1532-3, Yana Kisarazu-shi, Chiba 292-0812, JP (AllExceptUS)
Inventors: YAMAJI, Noboru; JP
NISHIMURA, Kouichi; JP
ABE, Kunitake; JP
OHARA, Osamu; JP
NAGASE, Takahiro; JP
NOMURA, Nobuo; JP
Agent: NAGAI, Shozo ; Yamanouchi Pharmaceutical Co., Ltd. Patent Dept. 17-1, Hasune 3-chome Itabashi-ku, Tokyo 174-8612, JP
Priority Data:
11/32174011.11.1999JP
2000-14402016.05.2000JP
Title (EN) NOVEL METALLOPROTEASE HAVING AGGRECANASE ACTIVITY
(FR) NOUVELLE METALLOPROTEASE PRESENTANT UNE ACTIVITE AGGRECANASE
Abstract:
(EN) A novel metalloprotease having an aggrecanase activity which causes joint diseases; a gene encoding this metalloprotease; a promoter of the above metalloprotease; a method of screening a drug with the use of the above metalloprotease; and compositions for inhibiting the degradation of proteoglycans which contain as the active ingredient a substance inhibiting the aggrecanase activity of the above metalloprotease.
(FR) L'invention concerne une nouvelle métalloprotéase ayant une activité aggrécanase qui provoque des maladies des articulations; un gène codant cette métalloprotéase; un promoteur de ladite métalloprotéase; un procédé de recherche de médicament utilisant cette métalloprotéase; ainsi que des compositions destinées à inhiber la dégradation de protéoglycanes qui renferment comme ingrédient actif une substance inhibant l'activité aggrécanase de ladite métalloprotéase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)