Search International and National Patent Collections

1. (WO2001034630) METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING CHROMOSOME 18q RELATED DISORDERS

Pub. No.:    WO/2001/034630    International Application No.:    PCT/US2000/030820
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Thu Nov 09 00:59:59 CET 2000
IPC: A61K 38/00
A61K 48/00
C07K 14/47
Applicants: MILLENNIUM PHARMACEUTICALS, INC.
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
CHEN, Hong
FREIMER, Nelson, B.
Inventors: CHEN, Hong
FREIMER, Nelson, B.
Title: METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING CHROMOSOME 18q RELATED DISORDERS
Abstract:
The present invention relates to the mammalian fsh30 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh30 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh30 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh30 gene molecules and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh30 genes and gene products and to using such compounds as therapeutic agents in the treatment of fsh30-related disorders, e.g., neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of fsh30-related disorders, e.g., neuropsychiatric disorders, including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment of these disorders.