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1. (WO2001034612) CHIRAL PHOSPHINES, TRANSITION METAL COMPLEXES THEREOF AND USES THEREOF IN ASYMMETRIC REACTIONS

Pub. No.:    WO/2001/034612    International Application No.:    PCT/US2000/030889
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Sat Nov 11 00:59:59 CET 2000
IPC: B01J 31/24
C07B 53/00
C07C 231/18
C07C 233/05
C07C 233/13
C07C 233/18
C07F 9/50
C07F 9/553
C07F 9/572
C07F 9/6506
C07F 9/655
C07F 9/6561
C07F 9/6596
Applicants: THE PENN STATE RESEARCH FOUNDATION
ZHANG, Xumu
Inventors: ZHANG, Xumu
Title: CHIRAL PHOSPHINES, TRANSITION METAL COMPLEXES THEREOF AND USES THEREOF IN ASYMMETRIC REACTIONS
Abstract:
Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include (R,S,S,R)-DIOP*. The ruthenium complex reduces enamide to the corresponding amine with up to 99% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.