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1. (WO2001034606) PHARMACEUTICALLY ACTIVE ISOINDOLINE DERIVATIVES

Pub. No.:    WO/2001/034606    International Application No.:    PCT/US2000/030770
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Fri Nov 10 00:59:59 CET 2000
IPC: C07D 209/46
C07D 209/48
C07D 413/04
C07D 471/04
C07D 487/04
Applicants: CELGENE CORPORATION
MAN, Hon-Wah
MULLER, George
Inventors: MAN, Hon-Wah
MULLER, George
Title: PHARMACEUTICALLY ACTIVE ISOINDOLINE DERIVATIVES
Abstract:
Isoindolin-1-one and Isoindoline-1, 3-dione substituted in the 2-position with an α-(3, 4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNFα and phosphodiesterase. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4,5-diaminoisoindoline-1,3-dione.