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Machine translation
1. (WO2001034603) BICYCLIC AND TRICYCLIC HETEROAROMATIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/034603    International Application No.:    PCT/US2000/030905
Publication Date: 17.05.2001 International Filing Date: 10.11.2000
Chapter 2 Demand Filed:    11.06.2001    
IPC:
C07D 217/26 (2006.01), C07D 237/30 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 519/00 (2006.01)
Applicants: NEUROGEN CORPORATION [US/US]; 35 Northest Industrial Road, Branford, CT 06405 (US) (For All Designated States Except US).
YUAN, Jun [US/US]; (US) (For US Only).
ALBAUGH, Pamela [US/US]; (US) (For US Only).
SHAW, Kenneth [US/US]; (US) (For US Only).
HUTCHISON, Alan [US/US]; (US) (For US Only)
Inventors: YUAN, Jun; (US).
ALBAUGH, Pamela; (US).
SHAW, Kenneth; (US).
HUTCHISON, Alan; (US)
Agent: SARUSSI, Steven, J.; McDonnell Boehnen Hulbert & Berghoff, Suite 3200, 300 South Wacker Drive, Chicago, IL 60606 (US)
Priority Data:
60/165,054 12.11.1999 US
Title (EN) BICYCLIC AND TRICYCLIC HETEROAROMATIC COMPOUNDS
(FR) COMPOSES HETEROAROMATIQUES BICYCLIQUES ET TRICYCLIQUES
Abstract: front page image
(EN)Disclosed are compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors and re therefore useful in the treatment of central nervous system (CNS) diseases and as probes for the localization of GABAA receptors in tissue samples. Also disclosed are intermediates useful in the preparation of these compounds.
(FR)On décrit des composés de formule (I) ainsi que leurs sels pharmaceutiquement acceptables. Dans la formule W, Q, X, X1, Y et Z sont tels que décrits dans le descriptif. Ces composés se lient avec une forte sélectivité et/ou une grande affinité au site benzodiazépine des récepteurs GABAA et sont par conséquent utiles dans le traitement des maladies du système nerveux central (SNC) et en tant que sondes permettant de localiser les récepteurs GABAA dans des échantillons de tissus. On décrit également des intermédiaires utiles dans la préparation de ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)