Search International and National Patent Collections

1. (WO2001034603) BICYCLIC AND TRICYCLIC HETEROAROMATIC COMPOUNDS

Pub. No.:    WO/2001/034603    International Application No.:    PCT/US2000/030905
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Sat Nov 11 00:59:59 CET 2000
IPC: C07D 217/26
C07D 237/30
C07D 471/04
C07D 487/04
C07D 519/00
Applicants: NEUROGEN CORPORATION
YUAN, Jun
ALBAUGH, Pamela
SHAW, Kenneth
HUTCHISON, Alan
Inventors: YUAN, Jun
ALBAUGH, Pamela
SHAW, Kenneth
HUTCHISON, Alan
Title: BICYCLIC AND TRICYCLIC HETEROAROMATIC COMPOUNDS
Abstract:
Disclosed are compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors and re therefore useful in the treatment of central nervous system (CNS) diseases and as probes for the localization of GABAA receptors in tissue samples. Also disclosed are intermediates useful in the preparation of these compounds.