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1. (WO2001034597) N-ARYL-(HOMOPIPERAZINYL)-CYCLOHEXYL AMINES AS 5-HT TRANSPORTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/034597 International Application No.: PCT/US2000/014020
Publication Date: 17.05.2001 International Filing Date: 19.05.2000
Chapter 2 Demand Filed: 18.05.2001
IPC:
C07D 401/14 (2006.01) ,C07D 403/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
08
linked by a carbon chain containing alicyclic rings
Applicants:
WYETH [US/US]; Five Giralda Farms Madison, NJ 07940-0874, US
Inventors:
GILBERT, Adam, Matthew; US
MEWSHAW, Richard, Eric; US
Agent:
ECK, Steven, R.; Wyeth Patent Law Department - 2B One Campus Drive Parsippany, NJ 07054 , US
WILEMAN, David Francis; c/o Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berkshire SL6 0PH, GB
Priority Data:
09/436,12908.11.1999US
Title (EN) N-ARYL-(HOMOPIPERAZINYL)-CYCLOHEXYL AMINES AS 5-HT TRANSPORTERS
(FR) AMINES DE N-ARYL-(HOMOPIPERAZINYL)-CYCLOHEXYL, UTILISEES COMME TRANSPORTEURS DE 5-HT
Abstract:
(EN) This invention provides novel compounds and methods and compositions using them in the treatment of central nervous system disorders, including depression and anxiety, the compounds having the formula (I) wherein Ar is an aryl, arylalkyl or a heteroaryl group; R1 and R2 are independently selected from hydrogen, alkyl of 1 to 12 carbon atoms which may be substituted or cycloalkyl of 3 to 10 carbon atoms which may be substituted; R3 is H, alkyl which may be substituted, cyclic alkyl which may be substituted, halogen, alkoxy, haloalkyl, OH, nitro, amino, CN, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl and alkylaminocarbonyl; or a pharmaceutically acceptable salt thereof.
(FR) Cette invention se rapporte à de nouveaux composés et à de nouveaux procédés, ainsi qu'à des compositions utilisant ces composés et ces procédés dans le traitement des troubles du système nerveux central, tels que la dépression et l'anxiété, ces composés étant représentés par la formule (I), où Ar représente un aryle, un arylalkyle ou un groupe hétéroaryle; R1 et R2 sont choisis séparément parmi hydrogène, alkyle de 1 à 12 atomes de carbone pouvant être substitué ou cycloalkyle de 3 à 10 atomes de carbone pouvant être substitué; R3 représente H, alkyle pouvant être substitué, alkyle cyclique pouvant être substitué, halogène, alcoxy, haloalkyle, OH, nitro, amino, CN, carboxy, alcoxycarbonyle, alkylcarbonyle, aminocarbonyle et alkylaminocarbonyle; et à un sel de ces composés acceptable sur le plan pharmaceutique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)