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Machine translation
1. (WO2001034590) PROCESS FOR MANUFACTURING SIMVASTATIN AND THE NOVEL INTERMEDIATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/034590    International Application No.:    PCT/IN1999/000063
Publication Date: 17.05.2001 International Filing Date: 11.11.1999
Chapter 2 Demand Filed:    27.07.2000    
IPC:
C07D 309/30 (2006.01)
Applicants: BIOCON INDIA LIMITED [IN/IN]; 20th K.M. Hosur Road Hebbagodi Bangalore 561 229 Karnataka (IN) (For All Designated States Except US).
SAMBASIVAM, Ganesh [IN/IN]; (IN) (For US Only).
SRIDHARAN, Madhavan [IN/IN]; (IN) (For US Only).
ACHARYA, Poornaprajna [IN/IN]; (IN) (For US Only).
MATHEW, Joy [IN/IN]; (IN) (For US Only)
Inventors: SAMBASIVAM, Ganesh; (IN).
SRIDHARAN, Madhavan; (IN).
ACHARYA, Poornaprajna; (IN).
MATHEW, Joy; (IN)
Agent: ANAND, Pravin; Anand & Anand, Advocates B-41, Nizamuddin East New Delhi 110 013 (IN)
Priority Data:
Title (EN) PROCESS FOR MANUFACTURING SIMVASTATIN AND THE NOVEL INTERMEDIATES
(FR) PROCEDE DE FABRICATION DE SIMVASTATINE ET DE NOUVEAUX INTERMEDIAIRES
Abstract: front page image
(EN)This invention describes the synthesis of simvastatin from lovastatin by converting the lovastatin to lova amide using a secondary amine and subsequent reaction with a metal amide base generated from n-butyl lithium and pyrrolidine and followed by treatment with methyl iodide to give desired C-methylated intermediate. This intermediate was further transformed to the final product, simvastatin. This method of production consumes lesser quantities of metal amide, gives fewer side reactions and a lowered overall cost of manufacture of simvastatin than other procedures reported.
(FR)La présente invention concerne la synthèse de simvastatine à partir de lovastatine par conversion de la lovastatine en amide lova au moyen d'une amine secondaire et d'une réaction ultérieure avec une base amide métallique produite à partir de n-butyle lithium et de pyrrolidine, puis par traitement à l'iodure de méthyle pour obtenir un intermédiaire C-méthylé désiré. Cet intermédiaire est ensuite transformé en un produit fini, la simvastatine. Ce procédé de fabrication nécessite moins d'amide métallique, provoque relativement peu d'effets secondaires, et le coût de fabrication de la simvastatine au moyen de ce procédé est inférieur à celui de tous les autres procédés connus.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)