WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2001034561) PROCESSES FOR THE PREPARATION OF SUMATRIPTAN AND RELATED COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/034561    International Application No.:    PCT/EP2000/010581
Publication Date: 17.05.2001 International Filing Date: 27.10.2000
Chapter 2 Demand Filed:    30.03.2001    
IPC:
C07C 303/40 (2006.01), C07C 311/35 (2006.01), C07D 209/14 (2006.01)
Applicants: BASF AKTIENGESELLSCHAFT [DE/DE]; 67065 Ludwigshafen (DE) (For All Designated States Except US).
HOLMAN, Nicholas, John [GB/GB]; (GB) (For US Only).
FRIEND, Christopher, Lyndon [GB/GB]; (GB) (For US Only)
Inventors: HOLMAN, Nicholas, John; (GB).
FRIEND, Christopher, Lyndon; (GB)
Agent: GOLDSCHEID, Bettina; c/o BASF Aktiengesellschaft, 67056 Ludwigshafen (DE)
Priority Data:
9926250.3 06.11.1999 GB
Title (EN) PROCESSES FOR THE PREPARATION OF SUMATRIPTAN AND RELATED COMPOUNDS
(FR) PROCEDES DE PREPARATION DU SUMATRIPTAN ET COMPOSES ASSOCIES
Abstract: front page image
(EN)The present invention relates to a process for preparing phenylhydrazines of formula (I) in which R represents CH2SO2NHCH3, CH2CH2SO2Ph, CH2CH2SO2NHMe or a group of structure (A), (B), (C), in which a diazonium salt of formula (II) in which X represents an anion derived from hydrochloric acid, sulphuric acid, acetic acid, phosphoric acid, tetrafluoroboric acid or hydrobromic acid is reduced by a dithionite salt. The resulting phenylhydrazines can be converted to the corresponding indole derivatives by the Fischer indole synthesis.
(FR)La présente invention se rapporte à un procédé de préparation de phénylhydrazines de formule (I) dans laquelle R représente CH2SO2NHCH3, CH2CH2SO2Ph, CH2CH2SO2NHMe ou un groupe de structure (A), (B), (C), consistant à réduire par un sel de dithionite un sel de diazonium représenté par la formule (II), dans laquelle X représente un anion dérivé de l'acide chlorhydrique, de l'acide sulfurique, de l'acide acétique, de l'acide phosphorique, de l'acide tétrafluoroborique ou de l'acide bromhydrique. Les phénylhydrazines résultantes peuvent être transformées en dérivés indole correspondants par une synthèse d'indole de Fischer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)