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1. (WO2001034190) LIVE BACTERIAL VACCINES AGAINST ESCHERICHIA COLI O157:H7

Pub. No.:    WO/2001/034190    International Application No.:    PCT/CA2000/001321
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Sat Nov 11 00:59:59 CET 2000
IPC: A61K 39/108
A61K 39/112
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA
PERRY, Malcolm, B.
CONLAN, J., Wayne
Inventors: PERRY, Malcolm, B.
CONLAN, J., Wayne
Title: LIVE BACTERIAL VACCINES AGAINST ESCHERICHIA COLI O157:H7
Abstract:
Disclosed are novel live bacterial vaccines against E. coli O157:H7, to treat or prevent colonization of the gastrointestinal tract of a vertebrate by the pathogen. The vaccines comprise an effective amount of non-pathogenic bacteria naturally expressing the O157 antigen or a structural mimic thereof as a part of their lipopolysaccharide. In a preferred embodiment, the non-pathogenic bacteria are selected from bacterial strains of the genus Salmonella or Citrobacter. The vaccines of the invention are particularly useful in maintaining cattle herds free of E. coli O157:H7 and in reducing carriage and fecal shedding of E. coli O157:H7 prior to slaughter, thus potentially reducing the clin ical incidence of E. coli O157:H7infections in humans.