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1. (WO2001034125) THERAPEUTIC USE AND FORMULATION OF (-)-TRAMADOL

Pub. No.:    WO/2001/034125    International Application No.:    PCT/GB2000/004287
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Thu Nov 09 00:59:59 CET 2000
IPC: A61K 31/135
A61K 31/485
A61K 33/24
Applicants: DARWIN DISCOVERY LIMITED
HUCKLE, Richard, Michael
Inventors: HUCKLE, Richard, Michael
Title: THERAPEUTIC USE AND FORMULATION OF (-)-TRAMADOL
Abstract:
Substantially single enantiomer (-)-tramadol, and its metabolites and structural and/or functional analogues, are useful for the prevention and/or treatment of one or more symptoms selected from nausea, vomiting, dizziness, blurred vision, drowsiness, somnolence, hallucinations, respiratory depression, constipation and euphoria. In particular, substantially single enantiomer (-)-tramadol, and its O-desmethyl metabolite, have been found to be potent anti-emetics.