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1. (WO2001034120) APPARATUS AND METHOD FOR PREPARING MICROPARTICLES USING IN-LINE SOLVENT EXTRACTION

Pub. No.:    WO/2001/034120    International Application No.:    PCT/US2000/041845
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Sat Nov 04 00:59:59 CET 2000
IPC: A61K 9/16
Applicants: ALKERMES CONTROLLED THERAPEUTICS INC. II
Inventors: LYONS, Shawn, L.
WRIGHT, Steven, G.
Title: APPARATUS AND METHOD FOR PREPARING MICROPARTICLES USING IN-LINE SOLVENT EXTRACTION
Abstract:
An emulsion is formed by combining two phases in a static mixer (140, 235). The outflow of the blending static mixer (130,230). The emulsion is conbined with an extraction liquid in a blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outlfow of the blending static mixer can be combined in a vessel (160), or through the use of a static mixer manifold (240) that includes a plurality of static mixers.